解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Toxicants can perturb cellular homeostasis by modifying phosphorylation-based signaling. In the present study, we examined the effects of cerulein, an inducer of acute pancreatitis, on keratin 8 (K8) phosphorylation. We found that cerulein dose-dependently induced K8 phosphorylation and perinuclear reorganization in P...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22186
更新日期:2016-12-01 00:00:00
abstract::Smoking increases the risk of cardiovascular disorders and leads to damage caused by inflammation and oxidative stress. The actin cytoskeleton is a key player in the response to inflammatory stimuli and is an early target of cellular oxidative stress. The purpose of this study was to investigate the changes in actin c...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22133
更新日期:2016-11-01 00:00:00
abstract::Trichloroethylene (TCE) is ubiquitous in our living environment, and prenatal exposure to TCE is reported to cause congenital heart disease in humans. Although multiple studies have been performed using animal models, they have limited value in predicting effects on humans due to the unknown species-specific toxicolog...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22142
更新日期:2016-11-01 00:00:00
abstract::Nickel nanoparticles (Ni NPs) are associated with reproductive toxicity. However, the mechanisms of reproductive toxicity are unclear. Our goal was to explore further reproductive toxicity induced by nickel nanoparticle and mechanisms involved in this process, including the role of oxidative stress and apoptosis. Acco...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22288
更新日期:2016-11-01 00:00:00
abstract::Four-week-old mice, weighing about 25-35 g were divided into five groups (8 mice in each group): vehicle control, low- (0.5 g/kg), middle- (1 g/kg), high- (3 g/kg), and exceptionally high-dose (5 g/kg). After first and second weeks of intraperitoneal exposure to AgNPs, biochemical, histopathological, and electron micr...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22104
更新日期:2016-08-01 00:00:00
abstract::Sulfur dioxide (SO2 ) is a ubiquitous air pollutant. The previous studies have documented the adverse effects of SO2 on nervous system health, suggesting that acutely SO2 inhalation at high concentration may be associated with neurotoxicity and increase risk of hospitalization and mortality of many brain disorders. Ho...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22093
更新日期:2016-07-01 00:00:00
abstract::Polychlorinated biphenyls (PCBs) are a class of organic pollutants that have been linked to pancreatic disease. However, their role in affecting the exocrine function of pancreas and the underlying mechanism remains elusive. In the present study, male C57 mice were treated with Aroclor 1254, a commercially available P...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22079
更新日期:2016-06-01 00:00:00
abstract::Titanium dioxide nanoparticles (TiO2 NPs) have been used in environmental management, food, medicine, and industry. But TiO2 NPs have been demonstrated to cross the blood-brain barrier and store up in the brain organization, leading to glutamate-mediated neurotoxicity. However, the neurotoxicity in the brain is not we...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22077
更新日期:2016-06-01 00:00:00
abstract::The aim of the study was to investigate the early effect of acute dichlorodiphenyltrichloroethane (DDT) exposure on the methylation status of the promoter region of two tumor suppressor genes: p53 and p16(INK4a) (p16) in rat liver. We analyzed their transcript and protein expression profiles concurrently with the exam...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22071
更新日期:2016-05-01 00:00:00
abstract::8-Hydroxy-2'-deoxyguanosine (8-OHdG) is the most common biomarker of oxidative DNA damage, it is formed by chemical carcinogens and can be measured in any species. Perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) are suspected genotoxic carcinogens through induction of reactive oxygen species that are r...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22034
更新日期:2016-02-01 00:00:00
abstract::Endotoxins exist anywhere including in water pools, dust, humidifier systems, and machining fluids. The major causal factor is endotoxins in many serious diseases, such as fever, sepsis, multi-organ failure, meningococcemia, and severe morbidities like neurologic disability, or hearing loss. Endotoxins are also called...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22033
更新日期:2016-02-01 00:00:00
abstract::Indium, a rare earth metal characterized by high plasticity, corrosion resistance, and a low melting point, is widely used in the electronics industry, but has been reported to be an environmental pollutant and a health hazard. We designed a study to investigate the effects of subacute exposure of indium compounds on ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22022
更新日期:2016-01-01 00:00:00
abstract::Although triphenyltin (TPT) compounds are ubiquitous pollutants in urbanised coastal environments in Asian regions, their toxicities to marine organisms are still poorly known. This study was designed to investigate the toxicity of triphenyltin chloride (TPTCl) on the rotifer Brachionus koreanus across different level...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22018
更新日期:2016-01-01 00:00:00
abstract::Tributyltin (TBT), a well-known endocrine disruptor, is an omnipresent environmental pollutant and is explicitly used in many industrial applications. Previously we have shown its neurotoxic potential on cerebral cortex of male Wistar rats. As the effect of TBT on other brain regions is not known, we planned this stud...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22009
更新日期:2015-12-01 00:00:00
abstract::Metals such as lead (Pb), magnesium (Mg), and iron (Fe) are ubiquitous in the environment as a result of natural occurrence and anthropogenic activities. Although Mg, Fe, and others are considered essential elements, high level of exposure has been associated with severe adverse health effects including cardiovascular...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22014
更新日期:2015-12-01 00:00:00
abstract::2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs) are persistent organic pollutants which coexist in environment, and human are co-exposed to these chemicals. Our present study was aimed to investigate the possible enhanced nonalcoholic fatty liver disease (NAFLD) in ApoE(-/-) mice co-exp...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22006
更新日期:2015-12-01 00:00:00
abstract::Wood dusts, as a group, are categorized as known human carcinogens, but the risks of exposure to specific types of wood dusts and the carcinogenic chemicals they contain are not well studied. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is linked to the carcinogenic action of specifi...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22007
更新日期:2015-12-01 00:00:00
abstract::Hypothyroxinemia induced by maternal mild iodine deficiency causes neurological deficits and impairments of brain function in offspring. Hypothyroxinemia is prevalent in developing and developed countries alike. However, the mechanism underlying these deficits remains less well known. Given that the myelin plays an im...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21997
更新日期:2015-11-01 00:00:00
abstract::Lead ions (Pb(2+) ) are toxic industrial pollutants associated with chronic inflammatory diseases in humans and animals. Previously, we found that Pb(2+) ions induce COX-2 gene expression via the EGF receptor/nuclear factor-κB signal transduction pathway in epidermoid carcinoma cell line A431. In this study, to see wh...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21976
更新日期:2015-09-01 00:00:00
abstract::Cantharidin is one of the major compounds from mylabris and it has cytotoxic effects in many different types of human cancer cells. Previously, we found that cantharidin induced cell death through cell cycle arrest and apoptosis induction in human lung cancer NCI-H460 cells. However, cantharidin-affected DNA damage, r...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21986
更新日期:2015-09-01 00:00:00
abstract::The aim of this study was to investigate the signaling pathways involved in the cyclooxygenase (COX)-2 regulation induced by nonylphenol (NP) in mouse testis Sertoli TM4 cells. Our results showed that treatment of TM4 cells with NP increased COX-2 protein expression and interleukin-6 (IL)-6 and prostaglandin E2 (PGE2)...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21987
更新日期:2015-09-01 00:00:00
abstract::There is increasing worldwide interest in developing of markers for tumor diagnosis and identification of individuals who are at high cancer risk. Cancer, like other diseases accompanied by metabolic disorders, causes characteristic effects on cell turnover rate, activity of modifying enzymes, and RNA/DNA modification...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21970
更新日期:2015-07-08 00:00:00
abstract::Perfluorooctane sulfonate (PFOS) is an animal carcinogen. However, the underlying mechanism in cancer initiation is still largely unknown. Recently identified microRNAs (miRNAs) may play an important role in toxicant exposure and in the process of toxicant-induced tumorigenesis. We used PFOS to investigate PFOS-induce...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21949
更新日期:2015-05-01 00:00:00
abstract::Tributyltin (TBT) and dibutyltin (DBT) are widespread environmental contaminants found in food, beverages, and human blood samples. Both of these butyltins (BTs) interfere with the ability of human natural killer (NK) cells to lyse target cells and alter secretion of the pro-inflammatory cytokine tumor necrosis factor...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21932
更新日期:2015-05-01 00:00:00
abstract::Domestic exposure to biomass smoke represents the second cause of chronic obstructive lung disease. Previous studies have shown that exposure of guinea pigs to wood smoke is capable of generating oxidative stress in lung tissue, and this may involve a failure at a mitochondrial level, given its close relation with the...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21922
更新日期:2015-04-01 00:00:00
abstract::Environmental estrogens are major cause of endocrine disruption in vertebrates, including aquatic organisms. Teleosts are valuable and popular models for studying the effects of endocrine disrupting chemicals (EDCs) in the environment. In the present study, we investigated the changes caused by exposure to the synthet...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21920
更新日期:2015-04-01 00:00:00
abstract::The acute toxicity of cylindrospermopsin (CYN) has been established in rodents, based on diverse intraperitoneal an oral exposure studies and more recently in fish. But no data have been reported in fish after subchronic exposure to cyanobacterial cells containing this cyanotoxin, so far. In this work, tilapia (Oreoch...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21904
更新日期:2015-03-01 00:00:00
abstract::Quinolines are aromatic nitrogen compounds with wide therapeutic potential to treat parasitic and microbial diseases. In this study, the genotoxicity of quinoline, 4-methylquinoline, 4-nitroquinoline-1-oxide (4-NQO), and diversely functionalized quinoline derivatives and the influence of the substituents (functional g...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21905
更新日期:2015-03-01 00:00:00
abstract::Increasing use of pesticides all over the world makes it necessary to reveal the toxic risk in populations of nontargeted organisms. Bendiocarb is one of the 12 insecticides recommended by the World Health Organization for use in malaria control in Africa, and is used against a variety of insects. The liver has an imp...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21887
更新日期:2015-02-01 00:00:00
abstract::T-2 toxin is the most toxic among mycotoxins and poses a potential health hazard for both humans and animals. At high doses, T-2 toxin can cause shock-like syndrome that can result in death. We evaluated the effect of time course and route of exposure on hepatic oxidative damage in mice and it is only such study so fa...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21895
更新日期:2015-01-01 00:00:00
abstract::Alpha-cypermethrin (α-CYP) is one of the most widely used insecticides. It may become an air pollutant and adversely affect the health. The present study was designed to determine whether treatment with N-acetyl cysteine (NAC), a well-known antioxidant, can be useful for the management of the deleterious effects of α-...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21891
更新日期:2015-01-01 00:00:00
abstract::The risk presented by β-blockers on aquatic organisms remains uncertain, particularly given the enantiospecific differences in toxicity of chiral β-blockers. In this study, the toxicity of two β-blockers, propranolol and metoprolol, was determined. The 96-h LC50 of propranolol in the zebrafish larvae was 2.48 mg/L, wh...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21867
更新日期:2014-12-01 00:00:00
abstract::Microcystin-LR (MC-LR) is a potent inhibitor of protein phosphatases 1 and 2A, and has potent hepatotoxicity and tumor promotion activity. Numerous studies on MC-LR toxicity have been conducted in rat hepatocytes, but few studies of the effects of microcystins on human hepatocytes have been done. In this study, HL7702...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21854
更新日期:2014-11-01 00:00:00
abstract::Sick building syndrome (SBS) is a set of several clinically recognizable symptoms reported by occupants of a building without a clear cause. Neuropathy target esterase (NTE) is a membrane bound serine esterase and its reaction with organophosphates (OPs) can lead to OP-induced delayed neuropathy (OPIDN) and nerve axon...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21839
更新日期:2014-10-01 00:00:00
abstract::Crude extract of Rheum palmatum L (CERP) has been used to treat different diseases in the Chinese population for decades. In this study, we investigated the effects of CERP on LS1034 human colorectal cancer cells in vitro and also examined possible mechanisms of cell death. Flow cytometric assays were used to measure ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21827
更新日期:2014-09-01 00:00:00
abstract::Punta Lara is located in the Río de la Plata estuary near industrial areas contaminated mainly by organic pollutants. In this work, the responses and status of hepatic biomarkers were studied in juvenile carp (Cyprinus carpio) by means of a 21-day field exposure in cages and collection of juvenile native fish (Leporin...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21823
更新日期:2014-08-01 00:00:00
abstract::Kupffer cells (KCs) are important in hepatic homeostasis and responses to xenobiotics. KCs are activated on interaction with endotoxin, releasing cytokines, and reactive oxygen species normally associated with increased gene expression, cellular growth, or hepatic injury. Ethanol-induced endotoxemia is one means of KC...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21814
更新日期:2014-08-01 00:00:00
abstract::To evaluate the allergic effect of airborne particulate matter (PM) on the airway, separated soluble supernatant (Sup) and insoluble precipitate (Pre) in suspended PM were inoculated into NC/Nga mice with a high sensitivity for mite allergens. Sup, Pre, or both Sup and Pre with or without pronase treatment were inocul...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21791
更新日期:2014-06-01 00:00:00
abstract::Hexavalent chromium (CrVI) is a highly toxic metal and a major environmental pollutant. Several studies indicate that CrVI exposure adversely affects reproductive function. We reported that maternal Cr exposure resulted in Cr accumulation in the reproductive organs of female offsprings. CrVI can cross the placental ba...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21810
更新日期:2014-05-01 00:00:00
abstract::Survival of juvenile freshwater mussels (Echyridella menziesii (Gray, 1843) formerly known as Hyridella menziesi) and crayfish (Paranephrops planifrons, White, 1842) decreased after four days exposure to microcystin-containing cell-free extracts (MCFE) of Microcystis sp. at concentrations typical of severe cyanobacter...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21774
更新日期:2014-05-01 00:00:00